Biomedical Frontiers: Fall 1996, Vol.4, No.1
Dermatology at Columbia

by David R. Bickers, M.D. Carl Truman Nelson Professor and Chairman, Department of Dermatology

Traditionally, dermatology has lagged behind other medical disciplines in the development of its scientific base. Fortunately, in recent years that has begun to change. Since I came to CPMC nearly three years ago, I have focused the research efforts of our department on applying the techniques of molecular genetics to unraveling questions that relate to a variety of skin diseases.

That effort is now beginning to bear fruit, with researchers such as Dr. Monica Peacocke focusing on the genetic basis of Cowden's syndrome, Dr. Angela Christiano developing genetic therapies for epidermolysis bullosa, and Dr. Maureen Poh-Fitzpatrick studying the genetics of porphyria. On another front, Dr. Vincent DeLeo is investigating the effect of UV radiation on signal transduction in cells. We are also strengthening our research abilities with joint appointments to clinical and basic science departments. Dr. Jean Gautier, who studies cell cycle checkpoints involved in Ataxia-telangiectasia, is the first faculty member to receive a joint appointment to the departments of dermatology and genetics and development.

At the same time, our clinical focus is stronger than ever. Dr. Zhi Yuan Wang is studying the anti-cancer effects of tea; Dr. Elizabeth Knobler is involved in clinical trials of phototherapy; and Dr. Richard Scher heads one of the world's leading centers for the study of nails and nail disorders. The combined strengths of our clinical and basic science programs continue to make Columbia a leader in the field of dermatology.