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Curriculum Vitae

Rudolph Leibel, M.D.

 

Date of Birth: January 1, 1942
Birth Place: Washington, D.C.
Citizenship: U.S.
Marital Status: Married, 2 children

ADDRESSES:
Office: Rockefeller University Columbia University
Hospital Box 181 Russ Berrie Bldg. 6
th Floor
1230 York Avenue 1150 St. Nicholas Avenue
New York, New York 10032

Phone: 212-327-8435 or 212-304-5257
Fax: 212-327-7150 or 212-304-5210
E-Mail:
leibel@rockvax.rockefeller.edu
(or)
rl232@columbia.edu

 

ACADEMIC TRAINING

TRAINEESHIP

BOARD QUALIFICATIONS

MILITARY SERVICE

PROFESSIONAL ORGANIZATIONS AND SOCIETIES

ACADEMIC APPOINTMENTS

1972-1973 Instructor in Pediatrics Massachusetts General Hospital Harvard University Medical School
1974-1978 Assistant Professor of Pediatrics Massachusetts General Hospital Harvard University Medical School
1978-1984 Assistant Professor Rockefeller University
1982-1993 Associate Professor of Clinical Pediatrics Cornell University Medical College
1985-1997 Associate Professor Rockefeller University
1992-1997 Head of Laboratory Rockefeller University
1993-1997 Professor of Pediatrics Cornell University Medical College
1997- Adjunct Professor of Pediatrics Cornell University Medical College
1997- Adjunct Professor Rockefeller University
1997 Professor of Pediatrics and Medicine Head, Division of Molecular Genetics College of Physicians and Surgeons Columbia University

 

HOSPITAL APPOINTMENTS

1972-1978 Assistant in Medicine Children's Hospital Medical Center, Boston
1972-1973 Assistant in Pediatrics Massachusetts General Hospital
1972-1975 Assistant Director of Pediatrics Cambridge Hospital, Cambridge, Massachusetts
1974-1975 Assistant Pediatrician Massachusetts General Hospital
1975-1978 Associate Pediatrician Massachusetts General Hospital
1975-1978 Associate Director of Pediatrics Cambridge Hospital
1978-1979 Assistant Physician Rockefeller University Hospital
1980-1985 Associate Physician Rockefeller University Hospital
1982-1993 Associate Attending Pediatrician New York Hospital
1985- Physician, Rockefeller University Hospital
1993- Attending Pediatrician, New York Hospital
1997- Attending Pediatrician, Babies Hospital of New York

 

OTHER APPOINTMENTS

 

HONORS

 

FELLOWSHIP AND GRANT SUPPORT

Current Grant Support

Pending Grant Support

 

DEPARTMENTAL AND UNIVERSITY COMMITTEES

HARVARD MEDICAL SCHOOL:

ROCKEFELLER UNIVERSITY:

CORNELL UNIVERSITY MEDICAL COLLEGE:

 

TEACHING EXPERIENCE AND RESPONSIBILITIES

1972-1978 Design and implementation of 3rd/4th year pediatric clerkship at Cambridge Hospital, Harvard Medical School
1976-1978 Lecturer, Endocrine Pathophysiology Section. Harvard Medical School.
1978-1997 Rockefeller University: Ph.D. thesis sponsorship of 3 Rockefeller University students. Ph.D. thesis committee for 4 additional students. One Howard Hughes Medical Student Scholar, 3 American Heart Association Medical Student Scholars, 20 Pew Scholars, ~10 postdoctoral fellows, 5 Cornell University Medical College Endocrine Fellows, over 20 college undergraduates, ~20 high school students.
1982-1997 See Cornell University Medical College above. As Director of medical student education in pediatrics, I designed the clerkship and have directly supervised, taught ,and prepared transcript material for ~120 consecutive 6 week clerkships, including > 1000 medical students. As chairman of residency advising, I have assisted ~150 students to obtain positions in pediatric training programs. I chaired the committee that designed the 4th year curriculum that is currently in place.

 

OTHER PROFESSIONAL ACTIVITIES

Committee Memberships:

Editorial Activities:

Study Sections:

Consultancy:

Other Administrative Positions:

 

CURRENT AREAS OF RESEARCH

 

PUBLICATIONS

Original Reports:

  1. Haenni, E., F.L. Joe, J.W. Howard and R.L. Leibel. A more sensitive and selective ultraviolet absorption criterion for mineral oil. J. Assoc. Off. Agri. Chem. 45:59-64, 1962.
  2. Leibel, R.L., J. Fangman and M. Ostrovsky. Chronic meningococcemia in childhood: Case report and review of the literature. Am. J. Dis. Child. 127:94-98, 1974.
  3. Porter, P.J., R.L. Leibel, et al. Municipal child health care services: A ten year reorganization. Pediatrics 58:704-712, 1976.
  4. Pollitt, E. and R.L. Leibel. Iron deficiency and behavior. J. Pediatr. 88:372-381, 1976.
  5. Leibel, R.L. A biologic radar system for the assessment of body mass. The model of a geometry sensitive endocrine system is presented. J. Theor. Biol. 66:297-06, 1977.
  6. Leibel, R.L. Thanatology and medical economics. N. Engl. J. Med. 296:511-513, 1977.
  7. Leibel, R.L. The complexities of dying. N. Engl. J. Med. 296:1239-1240, 1977 (correspondence).
  8. Leibel, R.L. The role of adipocyte geometry in eating behavior. Science 200:1504-1505, 1978.
  9. Leibel, R.L., D. Greenfield and E. Pollitt. Biochemical and behavioral aspects of sideropenia. Br. J. Haematol. 41:145-150, 1979.
  10. Chan, S., E. Pollitt and R.L. Leibel. Effects of nutrient cues on formula intake in 5-week old infants. Infant Behav. and Devel. 2:201-208, 1979.
  11. Leibel, R.L., V.E. Shih and S.I. Goodman, et al. Glutaric acidemia. A metabolic disorder causing progressive choreoathetosis. Neurology 30:1163-1168, 1980.
  12. Grinker, J., A.J. Strohmayer, J. Horowitz, J. Hirsch and R.L. Leibel. The effect of the metabolite glycerol on food intake and body weight in rats. Brain Res. Bull. 5:29-35, 1980.
  13. Leibel, R.L., A. Drewnowski and J. Hirsch. Effect of glycerol on weight loss and hunger in obese patients. Metabolism 29:1234-1236, 1980.
  14. Pollitt, E., R.L. Leibel and D. Greenfield. Brief Fasting, stress and cognition. Am. J. Clin. Nutr. 4:1526-1533, 1981.
  15. Leibel, R.L., E. Pollitt, I. Kim and F. Viteri. Studies regarding the impact of micronutrient status on behavior in man: iron deficiency as a model. Am. J. Clin. Nutr. 35:1211-1221, 1982.
  16. Pollitt, E., R.L. Leibel, N. Lewis and W. Mueller. The relation of growth to cognition in a well nourished pre-school population. Child Dev. 53:1157-1163, 1982.
  17. Pollitt, E., R.L. Leibel and D.B. Greenfield. Iron deficiency and cognitive test performance in preschool children. Nutr. Behav. 1:137-146, 1983.
  18. Leibel, R.L. Energy requirements in formerly obese patients. J. Obesity Weight Regulation 2:148-150, 1983.
  19. Leibel, R.L. and J. Hirsch. Diminished energy requirements in reduced-obese patients. Metabolism 33:164-170, 1984.
  20. Leibel, R.L., J. Hirsch, E.M. Berry and R.K. Gruen. A radioisotopic method for the measurement of lipolysis in small samples of human adipose tissue. J. Lipid. Res. 25:49-57, 1984.
  21. Carpentier, Y.A., M. Jeevanandam, A.P. Robin, J. Nordenstrom, R.E. Burr, R.L. Leibel, J. Hirsch, D.H., Elwyn and J.M. Kinney. Measurement of glycerol turnover by infusion of non-isotopic glycerol in normal and injured subjects. Am. J. Physiol. 247:916-928, 1984.
  22. Forse, R.A., R. Leibel, J. Hirsch, J. Askanazi, C. Michelson and J.M. Kinney. The adipocyte adrenergic receptor response in trauma and sepsis. Surgical Forum 35:6-8, 1984.
  23. Leibel, R.L. and J. Hirsch. A radioisotopic technique for the analysis of free fatty acid reesterification in human adipose tissue. Am. J. Physiol. 248:E140-E147, 1985.
  24. Leibel, R.L., J. Hirsch, E.M. Berry and R.K. Gruen. Alterations in adipocyte free fatty acid re-esterification associated with obesity and weight reduction in man. Am. J. Clin. Nutr. 42:198-206,1985.
  25. Leibel, R.L. A radioisotopic method for the measurement of free fatty acid turnover and adrenoreceptor response in small fragments of human adipose tissue. Int. J. Obesity 9:137-143, 1985.
  26. Leibel, R.L. and J. Hirsch. Characterization of obesity: Metabolic considerations. Ann. Int. Med. 103:1000-1002, 1985.
  27. Pollitt, E., C.S. Pollitt, R.L. Leibel and F.E. Viteri. Iron deficiency and behavioral development in infants and preschool children. Am. J. Clin. Nutr. 43:555-565, 1986.
  28. Leibel, R.L. and J. Hirsch. Site and sex related differences in adrenoreceptor status of human adipose tissue. J. Clin. Endocrinol. Metab. 64:1205-1210, 1987.
  29. Forse, A., R.L. Leibel, J. Askenazi, J. Hirsch, and J.F. Kinney. Adrenergic control of adipocyte lipolysis in trauma and sepsis. Ann. Surg. 206:744-751, 1987.
  30. Forse, A., R.L. Leibel, and R. Gagner. Effect of E.Coli endotoxin on adipocyte lipolysis. J.Surg.Res. 46:41-48, 1989.
  31. Fong, Y., M. Rosenbaum, K.J. Tracey, G. Raman, D.G. Hesse, D.E. Matthews, R.L. Leibel, J.M. Gertner, D.A. Fischman, and S.F. Lowry. Recombinant growth hormone enhances muscle myosin heavy-chain mRNA accumulation and amino acid accrual in humans. Proc.Natl.Acad.Sci. 86:3371-3374, 1989.
  32. Rosenbaum, M., R.L. Leibel, and J.M. Gertner. Acute inhibition of somatotroph response to human growth hormone-releasing hormone 1-44 occurs following 3 hours but not 1 hour of growth hormone infusion. Metabolism. 38:590-593, 1989.
  33. Leibel, R.L., A. Forse, and J. Hirsch. Effects of rapid glucose infusion on in-vivo and in-vitro free fatty acid re-esterification by adipose tissue of fasted obese subjects. Int. J. Obesity. 13:661-671, 1989.
  34. Rosenbaum, M., J.M. Gertner, and R.L. Leibel. Effects of systemic growth hormone (GH) administration on regional adipose tissue distribution and metabolism in GH-deficient children. J.Clin.Endocrinol.Metab. 69:1274-1281, 1989.
  35. Presta, E., R.L. Leibel, and J. Hirsch. Regional changes in adrenoceptor status during hypocaloric intake do not predict changes in adipocyte size or body shape. Metabolism. 39:307-315, 1990.
  36. Katzeff, H.L., M.U. Yang, E. Presta, R.L. Leibel, J. Hirsch, and T. Van Itallie. Effects of iopanoic acid on thyroid hormone metabolism during severe caloric restriction. Am J Clin Nutr. 52:263-266, 1990.
  37. Edens, N.K., R.L. Leibel, and J. Hirsch. Lipolytic effects on diacylglycerol accumulation in human adipose tissue in vitro. J. Lipid. Res. 31:1351-1359, 1990.
  38. Edens, N.K., R.L. Leibel, and J. Hirsch. Mechanism of free fatty acid re-esterification in human adipose tissue in vitro.J.Lipid.Res. 31:1423-1431, 1990.
  39. Bahary, N., R.L. Leibel, L. Joseph, and J.M. Friedman. Molecular mapping of the mouse db mutation. Proc.Natl.Acad.Sci. 87:8642-8646, 1990.
  40. Smiley, R.M., S. Paul, M. Browning, R.L. Leibel, and J. Hirsch. Protein phosphorylation in isolated human adipocytes-adrenergic control of the phosphorylation of hormone-sensitive lipase. Life Science. 47:849-858, 1990.
  41. Chua, S.C., R.L. Leibel and J. Hirsch. Food deprivation and age modulate neuropeptide expression in the murine hypothalamus and adrenal gland. Molecular Brain Research. 9:95-101, 1990.
  42. Leibel, R.L., E.M. Berry, and J. Hirsch. Metabolic and hemodynamic responses to endogenous and exogenous catecholamines in formerly obese subjects. Am. J. Physiol. 260:R785-R791, 1991.
  43. Lindberg, U.B., R.L. Leibel, J. Hirsch, P. Bjorntorp, and M. Rebuffe-Scrive. Effects of early pregnancy on regional adipose tissue metabolism. Horm.Metab.Res. 23:25-29, 1991.
  44. Rosenbaum, M., E. Presta, J. Hirsch, and R.L. Leibel. Regional differences in adrenergic receptor status of adipose tissue in adults and prepubertal children. J. Clin. Endoc. Metab. 73:341-347, 1991.
  45. Truett, G.E., N. Bahary, J.M. Friedman and R.L. Leibel. Rat obesity gene fatty (fa) maps to chromosome 5: Evidence for homology with the mouse gene diabetes (db) . Proc. Natl. Acad. Sci. 88:7806-7809, 1991.
  46. Bahary, N., G. Zorich, J.E. Pachter, R.L. Leibel, and J. Friedman. Molecular genetic linkage maps of mouse chromosomes 4 and 6. Genomics. 11:33-47, 1991.
  47. Friedman, J.M., R.L. Leibel, D.S. Siegel, J. Walsh and N. Bahary. Molecular mapping of the mouse ob mutation. Genomics. 11:1054-1062, 1991.
  48. Chua, S.C., A.W. Brown, J. Kim, K.L. Hennessey, R.L. Leibel, and J. Hirsch. Food deprivation and hypothalamic neuropeptide gene expression: Effect of strain background and the diabetes (db) mutation. Mol Brain Res. 11:291-299, 1991.
  49. Hirsch, J., R. Mackintosh, and R.L. Leibel. Nutritionally-induced changes in parasympathetic function. Brain Res Bull. 27:541-542, 1991.
  50. Hirsch, J., R.L. Leibel, R. Mackintosh, A. Aguirre. Heart rate variability as a measure of autonomic function during weight change in humans. Am.J. Physiol. 261:R1418-R1423, 1991.
  51. Leibel, R.L., J. Hirsch, B.E. Appel, G.C. Checani. Energy intake required to maintain body weight is not affected by wide variation in diet composition. Am. J. Clin. Nutr. 55:350-355, 1992.
  52. Rosenbaum, M., J.M Gertner, N. Gidar, J. Hirsch, and R.L. Leibel. Effects of systemic growth hormone (GH) administration on regional adipose tissue distribution and metabolism in children with idiopathic short stature. J. Clin. Endoc. Metab. 75:151-156, 1992.
  53. Bahary, N., J.E. Pachter, R. Felman, R.L. Leibel, S. Cram, and J.M. Friedman. Molecular mapping of mouse chromosome 4 and 6: use of a flow-sorted Robertsonian chromosome. Genomics. 13:761-769, 1992.
  54. Smoller, J.W., G.E. Truett, J. Hirsch, and R.L. Leibel. A molecular genetic method for genotyping fatty (fa/fa) rats. Am. J. Physiol. 33:R8-R11, 1993.
  55. Smoller, J.W., G.E. Truett, J. Hirsch, and R.L. Leibel.The Zucker fatty (fa) gene is not a mutation of corticotropin-releasing factor. Am. J. Physiol. 33: R12-R15, 1993.
  56. Rosenbaum, M., C.C. Malbon, J. Hirsch, and R.L. Leibel. Lack of beta3 adrenergic receptor effect on lipolysis in human subcutaneous adipose tissue. J Clin Endocrinol Metab 77:325-355, 1993.
  57. Bahary, N., D.A. Siegel, J. Walsh, Y. Zhang, L. Leopold, R. Leibel, R. Proenca, J. M. Friedman. Microdissection of proximal mouse Chromosome 6: identification of RFLP's tightly linked to the ob mutation. Mammalian Genome 4:511-515, 1993.
  58. Chua, S.C., M.H. Hansen, G.E. Truett, and R.L. Leibel. Utility of a c-JUN microsatellite in determining gene dosage for fatty (fa). Obesity Research 1:475-480, Nov. 1993.
  59. Edens, N.K., S.K. Fried, J.G. Kral, J. Hirsch, and R.L. Leibel. In vitro lipid synthesis in human adipose tissue from three abdominal sites. Am J Physiol. 265:E374-379. 1993.
  60. Chua, S.C., K.L. Hennessey, P. Zeitler and R.L. Leibel. The little mutation (lit) cosegregates with the growth hormone releasing factor receptor on mouse chromosome 6. Mammalian Genome 4:555-559, 1993.
  61. Fried, S.K., R.L. Leibel, and J.G. Kral. Lipolysis in intraabdominal adipose tissues of obese men and women. Obesity Research. 1:443-448, 1993.
  62. Power, L., S.C. Chua, and R.L. Leibel. Locus D1S21 contains exonic sequence from the C8 component of complement. Mammalian Genome. 5:125-126, 1994.
  63. Napolitano, A., B.B. Lowell, D. Damm, R.L. Leibel, E. Ravussin, D. Jimerson, D. Van Dyke, P. Daly, P. Chatis, T. White, B.M. Speigelman, and J.S. Flier. Adipsin blood levels and adipsin secretion by adipocytes in humans with normal and perturbed adipose tissue mass. International J. Obesity. 18:213-218, 1994.
  64. Wajnrajch, M.P., S.C. Chua, and R. L. Leibel. Human growth hormone-releasing hormone receptor (GHRHR) maps to chromosome 7 in somatic cell hybrids. Mammalian Genome. 5:595, 1994.
  65. Truett, G.E. , H.J Jacob, J. Miller, G. Drouin, N. Bahary, J.W. Smoller, E.S. Lander, and R.L. Leibel. Genetic map of rat chromosome 5 including the fatty (fa) locus. Mammalian Genome. 6:25-30, 1995.
  66. Leibel, R.L., M. Rosenbaum and J. Hirsch. Changes in energy expenditure resulting from altered body weight. N Engl J Med. 332:621-628, 1995.
  67. Kahle, E.B., K.G. Butz, O.E. Michaelis, R.L. Leibel and C.T. Hansen. The first documentation of reproduction in a genetically obese female fa/cp rat. ILAR News. 36:75-77, 1995.
  68. Kershaw, E.E., S.C. Chua, and R.L. Leibel. Localization of glucagon-like peptide-1 receptor gene (Glp1r) to proximal mouse chromosome 17 and its linkage to other markers. Mammalian Genome. 6:303-303, 1995.
  69. Kershaw, E.E., S.C. Chua, J.A. Williams, E.M. Murphy and R.L. Leibel. Molecular mapping of Pgm and C8b in the vicinity of the rat fatty locus using new SSR's for both genes. Genomics. 27:149-154, 1995.
  70. Green, E.D., M. Maffei, V.V. Braden, R. Procena, U. DeSilva, Y. Zhang, S.C. Chua, R.L. Leibel, J. Weissenbach, and J.M. Friedman. Mapping of the human obese (ob) gene on chromosome 7q31.3: Localization on a YAC contig containing 8 polymorphic genetic markers. Genome Research. 5:5-12, 1995.
  71. Aronne, L.J., R. Mackintosh, M. Rosenbaum, R.L. Leibel and J. Hirsch. Autonomic nervous system activity in weight gain and weight loss. Am J Physiol. 269:R222-R225, 1995.
  72. Wajnrajch, M.P., Gertner, J.M., Harbison, M.D., Chua Jr, S.C., & Leibel, R.L. Nonsense mutation in the human growth hormone releasing hormone receptor causes growth failure analogous to the little (lit) mouse. Nature Genetics. 12(1):88-90, 1996.
  73. Chua, S.C., W.K. Chung, X.S. Wu-Peng, Y. Zhang, S-M. Lui, L. Tartaglia, and R.L. Leibel. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science. 271:994-996, 1996.
  74. Rosenbaum M., E. Ravussin, D.E. Matthews, C. Gilker, R. Ferraro, S.B. Heymsfield, J. Hirsch and R.L. Leibel. A comparative study of different means of assessing long-term energy expenditure in humans. Am J Physiol. 270:R496-R504, 1996.
  75. Chung, W.K., L. Power-Kehoe, J. Goldberg-Berman, and R.L. Leibel. Molecular mapping of the murine tubby (tub ) mutation on chromosome 7. Genomics. 32:210-217, 1996.
  76. Meierfrankenfeld, B., M. Abelenda, H. Jauker, M. Klingenspor, E.E. Kershaw, S.C. Chua, R.L. Leibel, I. Schmidt. Perinatal energy stores and excessive fat deposition in genetically obese (fa/fa) rats. Am J Physiol. 270:E700-E708, 1996.
  77. Chung, W.K., L. Power-Kehoe, M. Chua, R.L. Leibel. Mapping of the OB receptor (OBR) to 1p in a region of non-conserved gene order from mouse and rat to human. Genome Research. 6:431-438, 1996.
  78. Chua, S.C., D.W. White, L. Power-Kehoe, X. S. Wu-Peng, S-M. Liu, N. Okada, E.E. Kershaw, L.A. Tartaglia, R.L. Leibel. Phenotype of fatty due to Gln269Pro mutation in the Leptin Receptor (Lepr). Diabetes. 45:1141-1143, 1996.
  79. Norman, R.A., R.L. Leibel, W.K. Chung, L. Power-Kehoe, S.C. Chua, W.C. Knowler, D.B. Thompson, C. Bogardus, and E. Ravussin. Absence of linkage of obesity and energy metabolism to markers flanking homologues of rodent obesity genes in Pima Indians. Diabetes. 45:1229-1232, 1996.
  80. Rosenbaum, M., M. Nicolson, J. Hirsch, S.B. Heymsfield, D. Gallagher, F. Chu, and R.L. Leibel. Effects of gender, body composition, and menopause on plasma concentrations of leptin. J Clin Endocrinol Metab. 81(9):3424-3427, 1996.
  81. Chung, W.K., L. Power-Kehoe, M. Chua, R. Lee, and R.L. Leibel. Genomic structure of the human OB receptor and identification of two novel intronic microsatellites. Genome Research. 6:1192-1199. 1996.
  82. Caprio, S., W.V. Tamborlane, C. Robinson, R. Leibel, S. McCarthy, A. Grosman, A. Belous, D. Maggs, and R.S. Sherwin. Hyperleptinemia an early manifestation of juvenile obesity. Relations to body fat depots and insulin concentrations. Am J Physiol. 271:E626-630. 1996.
  83. Duggirala, R., M.P. Stern, B.D. Mitchell, L.J. Reinhart, P.A. Shipman, O.C. Uresandi, W.K. Chung, R.L. Leibel, C.N. Hales, P. O'Connell, and J. Blangero. Quantitative variation in obesity-related traits and insulin precursors linked to OB gene region on human chromosome 7. Am J Hum Genet. 59:694-703. 1996.
  84. Rose, P.M., J.S. Lynch, S.T. Frazier, S.M. Fisher, W.K. Chung, Z. Fathi, R.L. Leibel, and P. Fernandes. Molecular genetic analysis of a human NPY Y1-like receptor: The human homolog of the murine "Y5" receptor may be a pseudogene. J. Biol. Chem. 272:3622-3627,1997.
  85. Wu-Peng, X.S., S. C. Chua, Jr., N. Okada, S-M. Liu, M. Nicolson, and R. L. Leibel. Phenotype of the obese Koletsky (f) rat due to Tyr763Stop mutation in the extracellular domain of the Leptin receptor (Lepr): evidence for deficient plasma - to - CSF transport of Leptin in both the Zucker and Koletsky obese rat. Diabetes. 46:513-518. 1997.
  86. Chagnon, Y.C., M. Lamothe, L. Preusse, M. Chagnon, J. Gagnon, A. Nadeau, W.K. Chung, L. Power-Kehoe, S.C. Chua, R.L. Leibel and C. Bouchard. Suggestive Genetic linkages between markers on human 1p32-p22 and body fat and insulin levels in the Quebec Family Study. Obesity Research. 5:115-121. 1997.
  87. Chung, W.K., M. Zheng, M. Chua, E. Kershaw, L. Power-Kehoe, I. Tsuji, X.S. Wu-Peng, J. Williams, S.C. Chua, and R.L. Leibel. Genetic modifiers of Leprfa which alter susceptibility to NIDDM. Genomics. 41:332-244. 1997.
  88. Echwald, SM ; Sorensen, TD; Sorensen, TIA; Tybjaerghansen, A; Andersen, T; Chung, WK;
  89. Leibel, RL; Pedersen, O. Amino-acid variants in the human leptin receptor: Lack of association to juvenile-onset obesity. BBRC 233: 248-252. 1997.
  90. Kahle, E.B., K.G. Butz, S.C. Chua, E. Kershaw, R. L. Leibel, T.W. Fenger, C.T. Hansen, and O.E. Michaelis. The rat corpulent (cp) mutation maps to the same interval on (PGM-GLUT1) rat chromosome 5 as the fatty (fa) mutation. Obesity Research. 5:142-145. 1997.
  91. Chung, W.K., S.C. Chua, G-H. Lee, and R.L. Leibel. PCR-RFLP and SSCP assays for the mouse obese (Lep ob ) mutation. Obesity Res.5:183-185. 1997.
  92. Aronne, L.J., R. Mackintosh, M. Rosenbaum, R.L. Leibel, and J. Hirsch. Cardiac Autonomic Nervous System Activity in Obese and Never-Obese Young Men. Obesity Research. 5:354-359,1997.
  93. Chung, W.K., L. Power-Kehoe, M. Chua, F. Chu, L. Aronne, Z. Huma, M. Sothern, J.N. Udall, B. Kahle, and R.L. Leibel. Exonic and intronic sequence variation in the human leptin receptor gene (LEPR). Diabetes 46:1509-1511. 1997.
  94. Chua, S. C., I. K. Koutras, L. Han, S-M. Liu, J. Kay, S.J. Young, W.K. Chung and R. L. Leibel. Fine structure of the murine leptin receptor gene: Splice site suppression is required to form two alternatively spliced transcripts. Genomics. 45:264-270, 1997.
  95. White, D.W., Wang, Y., Chua, S.C., Morgenstern, J.P., Leibel, R.L., Baumann, H., and Tartaglia, L.A. Constitutive and impaired signaling of leptin receptors containing the Gln>Pro extracellular domain fatty mutation. Proc Natl Acad Sci. 94:100657-10662, 1997.
  96. Rosenbaum, M., M. Nicolson, J. Hirsch, E. Murphy, and R.L. Leibel. Effects of weight change on plasma leptin concentrations and energy expenditure. J. Clin Endoc.Metab.82:3647-3654, 1997.
  97. Silver K, Walston, Chung W.K., Yao F., Parikh V.V., Andersen, Cheskin L.J., Elahi D., Muller D, Leibel R.L., and A.R. Shuldiner. The GLN223ARG and LYS656ASN Polymorphisms in the Human Leptin Receptor Do Not Associate with Traits Related to NIDDM or Obesity. Diabetes.46:1898, 1997.
  98. Zhang, Y., M. Olbort, K. Schwarzer, B. Nuesslein-Hildescheim, M. Nicholson, E. Murphy, T.J. Kowalski, I. Schmidt and R.L. Leibel. The leptin receptor mediates apparent autocrine regulatio of leptin receptor gene. BBRC, 240:492-495, 1997.
  99. Hirsch, J., L.C. Hudgins, R.L. Leibel and M. Rosenbaum. Diet composition and energy balance in humans. Am J Clin Nutr 67:551S-555S, 1998.
  100. Behn, P.S., W.K. Chung, C.A. Ianotti, K. Clement, M.A. Privince, C.M. Welling, J.B. McGill, S.Dagogo-Jack, P. Froguel, R.L. Leibel and M. A. Permutt. An analysis of leptin receptor gene varients in Type II Diabetes Mellitus. Diabetologia, In press, 1998.
  101. Sivitz, WI., Walsh, S., Morgan, D., Donohoue, P., Haynes, W., and Leibel, RL. Plasma leptin in diabetic and insulin-treated diabetic rats. Metabolism. In press, 1998.
  102. Vidal-Puig, A., M Rosenbaum, R.V. Considine, R.L. Leibel, G.L. Dohm, J.S. Flier, and B.B. Lowell. Effects of obesity and weight reduction on UCP2 and UCP3 gene expression in humans. J. Clin.Endocrinol. Metab. In press. 1998
  103. Boschmann, M., J. HellmÈr, M. Nicolson, M. Blum, X. S. Wu-Peng, R. M. Mackintosh and R. L. Leibel, Hyperleptinemia in neonatal Koletsky faK/faK rats precedes hyperinsulinemia and is disproportionate to fat mass. Submitted for Publication. 1997.
  104. Rosenbaum, M., V. Prieto, J. Hellmer, M. Boschmann, J. Krueger and R.L. Leibel and A. Ship. An exploratory investigation of the morphology and biochemistry of cellulite. J. Plas. Recon. Surg. In Press. 1997.
  105. Chung, W.K., K. Belfi, M. Chua, J. Wiley, R. Mackintosh, M. Nicolson, C.N. Boozer and R. L. Leibel. Heterozygosity for Lepob and Leprdb affects body composition and leptin homeostasis in adult mice. Am. J. Physiol. Accepted for Publication. 1998.
  106. Chagnon, Y.C., Chung, W.K., Perusse, L, Chagnon, M, Roy, S, Leibel, R.L., and Bouchard, C. Linkages and associations between the leptin receptor LEPR gene and human body composition in the Quebec Family Study (QFS). Submitted for Publication. 1998.
  107. Russell, C.D., R.N. Petersen, S.P. Rao, A. Prasad, R.E. Brolin, R.L. Leibel, Y. Zhang, and S.K. Fried. Regulation of leptin mRNA levels in human adipose tissue: depot differences and effects of insulin and dexamethasone. Submitted for Publication. 1998.
  108. Chung, W.K., L. Power-Kehoe, M. Chua, M. Zheng, L.D. Fricker, L. Aronne, B.Kohle, J. Goldberg-Berman and R.L. Leibel. Mapping of Carboxypeptidase E (CPE), the gene defective in the fat mouse, to chromosome 4q32; absence of functionally significant sequence variants in a sample of obese humans. Submitted for Publication. 1998.
  109. Kammerer, C.M., B.D. Mitchell, L.D. Atwood, S.H. Slifer, P. Shipman, M.L. Frazier, P. O’Connell, W.K. Chung, L. Power-Kehoe, S.C. Chua, R.L. Leibel, and M.P. Stern. Linkage analysis of body mass index in Mexican Americans to chromosomal regions homologous to those containing rodent obesity genes. Submitted for Publication. 1998.
  110. Karovenen, M.K., U. Personen, R. Sipilainen, A. Rissanen, H. Naukkarinen, W.K. Chung, R.L. Leibel, M. Laakso, M.Uusitupa and M. Koulu. Leptin Receptor gene variants associate with obesity related metabolic parameters. Submitted for publication. 1998.
  111. Boschmann, M., K.R. Segal, M. Rosenbaum, M. Galea, K. Vinaya and R.L. Leibel. Metabolic and hemodynamic responses to exercise in abdominal and femoral adipose tissue and in skeletal muscle. Submitted for Publication. 1998.
  112. Chung, W.K., M. Chua, A. Vidal-Puig, G. Solanes, M. Zheng, L. Wei, C. LeDuc, A. Eisberg, F. Chu, M. Schreier, L. Aronne, S. Caprio, M. Rosenbaum, B. Kahle, J. Flier, B. Lowell and R. L. Leibel. Sequence variants in uncoupling protein 2 (UCP2) associated with human obesity. Submitted for publication. 1998.
  113. Liu, S.M., R.L. Leibel and S.C. Chua. Partial Duplication in the Lepr db-Pas Mutation is a Result of Unequal Crossing Over. Submitted for Publication. 1998.

Reviews, Chapters and Editorials:

  1. Leibel, R.L. The differential diagnosis of hepatosplenomegaly. In: Graef, J.W. and Cone, T.E., eds., Manual of Pediatric Therapeutics, Little Brown and Company, 1974.
  2. Leibel, R.L. Phenylketonuria and psychosis. N. Engl. J. Med. 289:1040, 1973 (correspondence).
  3. Leibel, R.L. Behavioral and biochemical correlates of iron deficiency. J. Am. Diet. Assoc. 71:398-404, 1978.
  4. Pollitt, E., D. Greenfield and R.L. Leibel. Significance of Bayley scale score changes following iron therapy. J. Pediatr. 92:177-178, 1978 (editorial).
  5. Leibel, R.L., D. Greenfield and E. Pollitt. Iron biochemistry and behavior. In: Winick, M., ed., Nutrition: Pre- and Postnatal Development, Plenum Press, New York, 1979, pp. 383-439.
  6. Greenfield, D., E. Pollitt and R. Leibel. Behavioral effects of iron deficiency in a U.S. preschool population. In: Cesa-Bianchi, M. and F. Angeli, eds., Proceedings of the Biennial Conference of the International Society for the Study of Behavioral Development, Vol. l, Milan, Italy, 1979.
  7. Pollitt, E., R. Leibel and C. Thompson. Intellectual development of children with insufficient growth. In: Cesa-Bianchi, M. and F. Angeli, eds. Proceedings of the Biennial Conference of the International Society for the Study of Behavioral Development, Vol. 1, Milan, 1979, pp. 257-268.
  8. Pollitt, E., D. Greenfield and R.L. Leibel. U.S. needs and priorities in research on behavioral effects of nutritional deficiencies. In: Brozek, J., ed. Proceedings of the International Conference on Behavioral Effects of Energy and Protein Deficits. Washington, D.C., NIH Publication Number 79-1906, August, 1979.
  9. Pollitt, E., D. Greenfield and R.L. Leibel. Significance of Bayley scale score changes following iron therapy II. Infant Behav. and Devel. 2:235-236, 1979 (editorial).
  10. Pollitt, E. and R.L. Leibel. Biological and social correlates of failure to thrive. In: Greene, L.S. and F. Johnson, eds. Social and Biological Predictors of Nutritional Status, Physical Growth and Behavioral Development, Academic Press, New York, 1980, pp.173-200.
  11. Leibel, R.L., E. Pollitt and D. Greenfield. Methodologic problems in the assessment of nutrition-behavior interactions: A study of effects of iron deficiency on cognitive function in children. In: Miller, S., ed. Nutrition and Behavior, Franklin Institute Press, Philadelphia, 1981, pp. 299-301.
  12. Leibel, R.L. Some aspects of energy metabolism relevant to obesity. In: Garry, P.J., ed. Human Nutrition. Clinical and Biochemical Aspects. Proceedings of the Fourth Arnold O. Beckman Conference, Am. Assoc. Clin. Chem., Washington, D.C., 1981, pp. 239-254.
  13. Pollitt, E., N. Lewis and R.L. Leibel. Iron deficiency and play behavior in pre-school children. In: Garry, P.J., ed. Human Nutrition. Clinical and Biochemical Aspects. Proceedings of the Fourth Arnold O. Beckman Conference, Am. Assoc. Clin. Chem. Washington, D.C., 1981, pp. 290-301.
  14. Leibel, R.L. Commentary on obesity in infancy and childhood. Nutrition Section, American Academy of Pediatrics. Pediatrics 68:880-882, 1981.
  15. Pollitt, E. and R.L. Leibel, eds. Iron Deficiency: Brain Biochemistry and Behavior. Raven Press, New York, 1982.
  16. Pollitt, E., F. Viteri, C. Sacco-Pollitt and R.L. Leibel. Iron deficiency and cognitive performance of pre-school Guatemalan children. In: Pollitt, E. and R.L. Leibel, eds. Iron Deficiency: Brain Biochemistry and Behavior, Raven Press, New York, 1982, pp. 195-208.
  17. Leibel, R.L., E. Berry and J. Hirsch. The biochemistry and development of adipose tissue in man. In: Conn, H.L., Jr., E.A. DeFelice and P.T. Kuo, eds. Health and Obesity, Raven Press, New York, 1983, pp. 21-48.
  18. Pollitt, E., C. Garza, and R.L. Leibel. Nutrition and public policy. In H.W. Stevenson and A.E. Siegal, Eds. Child Development Research and Public Policy. Volume One. University of Chicago Press. Chicago, Illinois. 1984. pp 421-470.
  19. Hirsch, J. and R.L. Leibel. What constitutes a sufficient psychobiologic explanation for obesity? In: Stunkard, A.J. and E. Stellar, eds. Eating and its Disorders, Raven Press, New York, 1984, pp.121-130.
  20. Leibel, R.L. Obesity. In: Guesry, P.R. et al, eds. Clinical Nutrition of the Young Child, Raven Press, New York, 1986, pp. 155-174.
  21. Leibel, R.L., E.M. Berry and J. Hirsch. In-vivo evidence for catechol responsive brown adipose tissue in obese patients. In: Recent Advances in Obesity Research: V, Proceedings of the 5th International Congress on Obesity, Jerusalem, 1986, John Libbey & Company, Ltd., England, 1987, pp. 109-115.
  22. Hirsch, J, and R.L. Leibel. New light on obesity (Editorial). N.Engl.J.Med. 318:509-510, 1988.
  23. Hirsch, J, and R.L. Leibel. Energy expenditure and body-weight gain. (Correspondence). N. Engl.J. Med. 319:519, 1988.
  24. Rosenbaum, M., and R.L. Leibel. Pathophysiology of childhood obesity. Advances in Pediatrics 35:73-137, 1988.
  25. Rosenbaum, M., and R.L. Leibel. Obesity in childhood. Pediatrics in Review. 11:43-55, 1989.
  26. Hirsch, J., S.K. Fried, N.K. Edens, and R.L. Leibel. The fat cell. Med. Clin. N. Amer. 73:83-96, 1989.
  27. Leibel, R.L., N.K. Edens and S.K. Fried. Physiologic basis for the control of body fat distribution in humans. Ann.Rev.Nutr. 9:417-443, 1989.
  28. Leibel, R.L. The roles of nature and nurture in childhood obesity. Bull.N.Y.Acad.Med. 65:1121-1126. 1989.
  29. Leibel, R.L., N. Bahary, and J.M. Friedman. Genetic variation and nutrition in obesity: Approaches to the molecular genetics of obesity. In A.P. Simopoulos and B. Childs, Eds. Genetic Variation and Nutrition. Karger. Basel. pp. 90-101. 1990.
  30. Leibel, R.L. and N. Edens. Control of acylglyceride stores in human adipose tissue: Re-esterification and lipolysis. Comparability of in vivo and in vitro findings. In Bray, G.A., D. Ricquier, and B. Spiegelman, Eds. Obesity: Towards a Molecular Approach. UCLA Symposia on Molecular and Cellular Biology. pp. 189-201. 1990.
  31. Leibel, R.L. Is obesity due to a heritable difference in "set point" for adiposity. West.J.Med. 153:429-431, 1990.
  32. Friedman, J.M., R.L. Leibel, N. Bahary. Genetic analysis of complex disorders: Molecular mapping of obesity genes in mice and humans. Mammalian Genome. 1:130-144, 1991.
  33. Friedman, J.F., R.L. Leibel, N.B. Bahary, D.A. Siegel, and G. Truett. Genetic analysis of complex disorders in mice: Molecular mapping of obesity genes. Proceedings of the New York Academy of Science. 630:100-115, 1991.
  34. Leibel, R.L., M. Rosenbaum, N.K. Edens, and J. Hirsch. In-vitro vs. in-vivo measures of lipolysis and re-esterification in human adipose tissue. in Y. Oomura, S. Tarui, S. Inoue and T. Shimazu eds. Progress In Obesity Research 1990. John Libbey and Co Ltd. London. pp. 237-243, 1991.
  35. Hirsch, J., and R.L. Leibel. A biologic basis for human obesity. J. Clin. Endocrinol. Metab. 73:1153-1157, 1991.
  36. Hirsch, J., R.L. Leibel, and S.C. Chua. A clinical perspective on peptides and food intake: Pharmacological treatment of obesity. Am. J. Clin. Nutr. 55:296S-298S, 1992.
  37. Hirsch, J., R.L. Leibel, and N.K. Edens. Cellular corollaries of energy expenditure. In J.M. Kinney and H.N. Tucker Eds. Energy Metabolism: Tissue Determinants and Cellular Corollaries. Raven Press. New York. pp. 525-532. 1992.
  38. Leibel, R.L. Fat as fuel and metabolic signal. Nutr. Reviews 50:12-16, 1992.
  39. Friedman, J.M., and R.L. Leibel. Tackling a weighty problem. Cell 69:217-220, 1992.
  40. Leibel, R.L., N. Bahary, and J.M. Friedman. Strategies for the molecular genetic analysis of obesity in humans. Crit. Rev. Food Sci. Nutr. 33(4/5): 351-358, 1993.
  41. Leibel, R.L., M. Dufour, V.S. Hubbard and W.E.M. Lands. Alcohol and calories: A matter of balance. Alcohol. 10:429-434, 1993.
  42. Chua, S.C. and R.L. Leibel. Molecular genetic approaches to obesity. In C. Bouchard ed. Genetics of Obesity. CRC Press. Boca Raton. pp. 213-222, 1994.
  43. Leibel, R.L. Obesity: a game of inches. Pediatrics. 95:131-132,1995.
  44. Leibel, R.L. and J. Hirsch. The molecular biology of obesity. In Brownell, K.D. and C.G. Fairburn eds. Comprehensive Textbook of Eating Disorders and Obesity. Guilford Press, New York. pp. 450-456. 1995.
  45. Leibel, R.L., S.C. Chua, and W.K. Chung. Animal models of genetic obesity. In A. Angel, H. Anderson, C. Bouchard, D. Lau, L. Leiter and R. Mendelson eds. Progress in Obesity Research: 7. John Libbey & Company, Ltd. London/7th International Congress on Obesity. pp. 263-271, 1996.
  46. Chua, S.C. and R. L. Leibel. An Ounce of Prevention. (Editorial). J Pediatrics. 128:591-593, 1996.
  47. Klish, W.K., S.S. Baker, C.A. Flores, M.K. Georgieff, A.M. Lake, R.L. Leibel, J.N. Udall, M. Cheney, P.N. Daniels, S.S. Harris, V.S. Hubbard, E. Levin, A. Prendergast, A.E. Smith, E. Yetley, R. Yip, S. Zlotkin, R.M. Lauer, and E.F. Bell. Aluminum toxicity in infants and children. Pediatrics. 97(3):413-416, 1996.
  48. Gidding SS. Leibel RL. Daniels S. Rosenbaum M. Van Horn L., and G.R. Marx. Understanding obesity in youth. A statement for healthcare professionals from the Committee on Atherosclerosis and Hypertension in the Young of the Council on Cardiovascular Disease in the Young and the Nutrition Committee, American Heart Association. Circulation. 94(12):3383-7, 1996.
  49. Leibel, R.L., S.C. Chua, Jr., and W.K. Chung. Molecular genetic analysis of complex metabolic phenotypes: approaches to obesity and NIDDM. In L.A. Weston and L.M. Savage eds. Obesity Advances in Understanding and Treatment. International Business Communications, Southborough, MA. pp. 1.4.1-1.4.15, 1996.
  50. Chua, S.C. and R.L. Leibel. Obesity genes: Molecular and metabolic mechanisms. Diabetes Reviews. 5:2-7, 1997.
  51. Leibel, R.L. And finally, genes for human obesity. Nature Genetics. 16:218-220, 1997.
  52. Rosenbaum, M., R.L. Leibel, and J. Hirsch. Medical Progress: Obesity. N Engl J Med. 337:396-407, 1997.
  53. Leibel, R.L., W.K. Chung and S.C. Chua, Jr. The molecular genetics of rodent single gene obesities. J. Biol. Chem. 272:31937-31940, 1997.
  54. Albu, J., D. Allison, C.N. Boozer, S. Heymsfield, H. Kissileff, A. Kretser, K. Krumhar, R.L. Leibel, C. Nonas, X. Pi-Sunyer, T. VanItallie, E. Wedral. Obesity Solutions: Report of a Meeting. Nutrition Reviews. 55: 150-156, 1997.
  55. Kahle, E.B., R.L. Leibel, D.W. Domaschko, S.G. Raney and K.T. Mann. Obesity Genes and Insulin Resistance. Ann NY Acad Sci. 827:35-49, 1997.
  56. Rosenbaum, M. and R.L. Leibel. The Physiology of Body Weight Regulation: Relevance to Etiology of Obesity in Children in The Causes and Health Consequences of Obesity in Children and Adolescents. Pediatrics (supplement) 101:525-539, 1998.
  57. Zhang, YY and R.L. Leibel. Molecular Physiology of Leptin and Its Receptor. Growth: Genetics and Hormones. Growth: Genetics and Hormones. In Press. 1998
  58. Rosenbaum, M and R.L. Leibel. Leptin: A molecule integrating somatic energy stores, energy expenditure and fertility. Trends in Endocrinology and Metabolism. In Press. 1998.

 

Recent Abstracts

  1. Chung, W., Markel, D., Chua, S., Leibel, R. Molecular genetics of obesity/diabetes. J. Cellular Biochem. 18:158, 1994.
  2. Chung, W. and Leibel, R. Characterization and Mapping to Mid-Chromosome 10 of a New Neurological Mutation, Apathetic (ap). Workshop in mouse molecular neurogenetics. Jackson Laboratory, Bar Harbor, Maine. 1994.
  3. Leibel, R.L., S.C. Chua, and W.K. Chung. Animal models of genetic obesity. Proceedings of the 7th International Congress of Obesity. Toronto, Ontario, Canada. Intl. J. Obesity. 18(Suppl. 2):42, 1994.
  4. Tenenbaum, R., F.Y. Ochoa, M.L. Sassano, S.C. Chua, R.L. Leibel and L.A. Campfield. Altered insulin secretion from the pancreas of pre-obese Zucker rat pups: Evidence for an early and persistent genetic defect. Proceedings of the 7th International Congress of Obesity. Toronto, Ontario, Canada. Intl. J. Obesity. 18(Suppl. 2):67, 1994.
  5. Segal, K.R., and R. Leibel. Muscle efficiency during exercise in lean and obese men. FASEB J. 8:A700, 1994.
  6. Aronne, J., R.M. Mackintosh, R.L. Leibel, M. Rosenbaum and J. Hirsch. Autonomic nervous system activity and energy expenditure during weight loss and weight gain. USDA Symposium on Energy Metabolism. Beltsville, MD., May, 1994.
  7. Devoto, R, CS Fann, J Ott, RA Norman, E Ravussin, C Bogardus, L Power-Kehoe, WK Chung, SC Chua, Jr., RL Leibel. Genetic mapping of obesity in humans by analysis of marker loci syntenic with rodent obesity genes. European Society of Human Genetics. May 1995. Medizinische Genetik 2: 116, 1995.
  8. Norman, RA, WK Chung, L Power-Kehoe, SC Chua, RL Leibel, M Devoto, C Fann, J Ott, C Bogardus and E Ravussin. Genetic linkage studies of genes homologous to rodent obesity genes in Pima Indians. American Society for Human Genetics. 1995.
  9. Norman, RA, RL Leibel, C Bogardus, E Ravussin. Genome scan for linkages of obesity to polymorphic DNA markers in Pima Indians. North American Society for the Study of Obesity.(NAASO). Baton Rouge, La. October, 1995.
  10. Chung, WK, L Power-Kehoe, JF Gusella, PM Conneally, Venezuelan-United States Collaborative Research Group, NS Wexler, and RL Leibel. Genetic map of 1p31 in region homlogous to mid-murine chromosome 4. 2nd Chromosome One Meeting, Vienna Austria. September 1995.
  11. Chung, WK, SC Chua and RL Leibel. Molecular genetics of murine non-insulin dependent diabetes mellitus. The Biology and Genetics of Complex Mammalian Traits. Jackson Laboratory. September 1995.
  12. Segal, K.R., M. Rosenbaum, B. Chatr-Aryamontri, E. Murphy, D. Guvakov, J. Hirsch, R.L. Leibel. Impact of weight change on muscle efficiency during exercise (abstract). FASEB J. 9:A438 1995.
  13. Simoneau JA, Rosenbaum M, Segal K, Hirsch J, Leibel RL. Changes in human skeletal muscle histochemical characteristics following maintenance of 10% reduction in body weight. Canadian Journal of Applied Physiology 20: 46P, 1995.
  14. Morgan, M.M., P.A. Donohoue, T.L. Burns, T. Zirkel, G.C. Becker, L. Power-Kehoe, W.K. Chung, S.C. Chua, Jr., and R.L. Leibel. A polymorphism of D1S85 (VC85) is associated with obesity in the population of Muscatine, Iowa. Circulation. 91:929, 1995.
  15. Burns, T.L., P.A. Donohoue, and R.L. Leibel. Identification of obesity genes using sib-pairs linkage analysis: The Muscatine Study. Proceedings of the American Heart Association: 35th Annual Conference on Cardiovascular Disease Epidemiology and Prevention. San Antonio, Texas - March 8-11, 1995.
  16. Devoto, R, Duggirala, R, J Blangero, R Leibel, P O’Connell, and M Stern. Linkage of markers on human chromosome 7 with obesity related traits in Mexican Americans. Proceedings of the NAASO-SSIB Annual Conference- Pennington Biomedical Center - Baton Rouge, Louisiana, October 12-17, 1995.
  17. Morgan, MM, PA Donohoue, TL Burns, GC Becker, CL Binder, and RL Leibel. Polymorphism of D1S85 (VC85) is associated with obesity in Muscatine, Iowa. Journal of Investigative Medicine. 43:462A, 1995.
  18. Wajnrajch, MP, JM Gertner, MB, MD Harbison, SC Chua, and RL Leibel. GLU72 Stop mutation in the growth hormone releasing hormone receptor (GHRHR) causes growth failure analogous to that of the little mouse. General Clinical Research Centers Conference, March 6-9, 1996.
  19. Leibel, RL. The molecular physiology of weight regulation in rodents and humans. The International Society of Endocrinology and The Endocrine Society - 10th International Congress of Endocrinology (Volume II: June 12-15, 1996) p. L10-683. Plenary Lecture.
  20. Wajnrajch, MP, JM Gertner, T Moshang, P Saenger, RL Leibel. Isolated growth hormone (GH) deficiency, type II (IGHD II) caused by substitution of arginine by histidine in C-terminal portion of the GH molecule. The International Society of Endocrinology and The Endocrine Society - 10th International Congress of Endocrinology (Volume II: June 12-15, 1996) p. P2-313.
  21. Kahle, E.B., K.G. Butz, R.L. Leibel, C.T. Hansen, S.J. Bhathena and O.E. Michaelis. Glucose homeostasis in three interstrains (La/N-BN/Crl cp/cp; Zuc-13M-BN/Crl fa/fa; and Zuc 13M-LA/N fa/cp) of genetically obese rats. In E. Shafrir ed. Lessons from Animal Diabetes VI: 75th Anniversary of the Insulin Discovery. Birkhauser, Boston, 1996.
  22. Sivitz, WI, P Donohoue, and RL Leibel. Plasma leptin levels in diabetic and insulin-treated diabetic rats. AFCR Regional Meeting - Chicago, Illinois, September 19-21, 1996.
  23. Wajnrajch, MP, JM Gertner, MB, MD Harbison, SC Chua, and RL Leibel. GLU72 Stop mutation in the growth hormone releasing hormone receptor (GHRHR) causes growth failure analogous to that of the little mouse. General Clinical Research Centers Conference. March 6-9, 1996.
  24. Leibel, RL. The molecular physiology of weight regulation in rodents and humans. The International Society of Endocrinology and The Endocrine Society - 10th International Congress of Endocrinology (Volume II: p. L10-683.) Plenary Lecture. June 12-15, 1996.
  25. Wajnrajch, MP, JM Gertner, T Moshang, P Saenger, RL Leibel. Isolated growth hormone (GH) deficiency, type II (IGHD II) caused by substitution of arginine by histidine in C-terminal portion of the GH molecule. The International Society of Endocrinology and The Endocrine Society - 10th International Congress of Endocrinology (Volume II: p. P2-313.) June 12-15, 1996.
  26. Kahle, E.B., K.G. Butz, R.L. Leibel, C.T. Hansen, S.J. Bhathena and O.E. Michaelis. Glucose homeostasis in three interstrains (La/N-BN/Crl cp/cp; Zuc-13M-BN/Crl fa/fa; and Zuc 13M-LA/N fa/cp) of genetically obese rats. In E. Shafrir ed. Lessons from Animal Diabetes VI: 75th Anniversary of the Insulin Discovery. Birkhauser, Boston. 1996.
  27. Russell, C., R.N. Petersen, S. Papaspyrou-Rao, R. Brolin, Y. Zhang, R.L. Leibel, and S.K. Fried. Insulin and dexamethasone increase leptin mRNA in human Subcutaneous adipose American Diabetes Association, 1996.
  28. Sivitz, WI, P Donohoue, and RL Leibel. Plasma leptin levels in diabetic and insulin-treated diabetic rats. AFCR Regional Meeting - Chicago, Illinois. September 19-21, 1996.
  29. Leibel, R.L. Recent advances in understanding the molecular physiology of weight regulation. 17th Annual Meeting of the Japan Society for the Study of Obesity. Oita, Japan. November 14-15, 1996.
  30. Leibel, R.L. Leptin and the leptin receptor. Japan-U.S. Cooperative Medical Science Program. Shirahama, Wakayama, Japan. December 2, 1996.
  31. Leibel, R.L. Recent advances in understanding the molecular physiology of weight regulation. 17th Annual Meeting of the Japan Society for the Study of Obesity. Oita, Japan, November 14-15, 1996.
  32. Leibel, R.L. Leptin and the leptin receptor. Japan-U.S. Cooperative Medical Science Program. Shirahama, Wakayama, Japan, December 2, 1996.
  33. Wajnrajch, MP, Dannies, P., Kim, S., Gertner, J.M., Moshang, T and R.L. Leibel. Pathophysiology of Autosomal Dominant GH Deficiency 79th Annual Meeting of the Endocrine Society.P1-84. Pg 155. 1997.
  34. Leibel, R.L., Single Gene Obesities in Rodents: Possible Relevance to Human Obesity (abstract), in Proceedings of a symposium in Little Rock, Arkansas, March 4, 1997, Journal of Nutrition, 127:1908S.
  35. Segal, K.R., M. Rosenbaum, M. Galea, K. Vinaya, R.L. Leibel and M. Boschmann. Muscle blood flow and lactate and glycerol response to exercise are gender-dependent. Experimental Biology, (FASEB J. 11:A143) New Orleans, La. 1997.
  36. Boschmann, M.., M. Rosenbaum, K. Segal, K. Vinaya, M. Galea and R.L. Leibel. Metabolic and hemodynamic effects of exercise in abdominal and femoral subcutaneous adipose tissue. Experimental Biology. (FASEB J 11:A506). New Orleans, La.. 1997.
  37. Rosenbaum, M., V. Prieto, J. Hellmer, M. Boschmann, J. Krueger, R.L. Leibel and A. Ship. Cellulite: morphology and biochemistry. Society for Aesthetic Plastic Surgery. 1997.
  38. Simoneau, JA., M. Rosenbaum, M. Neverova, J. Hirsch, R.L. Leibel and C.H. Warden. Skeletal muscle UCP-2 content is increased in subjects maintaining a 10% reduction in body weight. N. Amer. Assoc. Study Obesity. 1997.
  39. Solanes, G., C-Y. Zhang, V.S. Susulic, D. Grujic, T. Hollenberg, W.K. Chung, R.L. Leibel, and B. Lowell. Transgenic assessment of leptin gene transcription and characterization of the ob2j mutation. American Diabetes Association. 1997.
  40. Silver, K., J. Walston, W.K. Chung, F. Yao, V.B. Parikh, R. Andersen, L.J. Cheskin, D. Elahi, D. Muller, R.L. Leibel and A.R. Shuldiner. Leptin (ob) receptor polymorphism in human obesity. American Diabetes Association, 1997.
  41. M. Boschmann, M. Rosenbaum, K.R. Segal and R.L. Leibel: Metabolische und haemodynamische Veraenderungen im abdominalen und femoralen Fettgewebe sowie im Muskel unter Bewegungsaktivit”t. Jahrestagung der Deutschen Adipositas-Gesellschaft, Leipzig, Germany. 1997.
  42. Behn, R.S., W.K. Chung, J. B. McGill, S Dagogo-Jack, P. Froeguel, R.L. Leibel, M. A. Permutt. Leptin Receptor Gene Variant Frequency and Relationship to Type 2 Diabetes in African Americans and Nigerians. American Diabetes Association, Chicago, Ill. 1998.
  43. Leibel, R.L., Advances in the Pathophysiology of Obesity. 80th Annual Meeting of the Endocrine Society, New Orleans, La. 1998.
  44. Leibel, R.L., Genetic and Molecular Aspects of Obesity: Recent Findings, Enzymes, Receptors and Drugs in Obesity and Artherosclerosis, Toronto, Can., 1998.
  45. Dannies, P.S., M.S. Lee, S.S. Kim, M.J. Wajnrajch, J.M. Gertner, R.L. Leibel, Co-Expression of Human (32-71) Growth Hormone with Wild Tupe Directly Reduces Expression of Wild Type Growth Hormone, 80th Annual Meeting of The Endocrine Society, 1988.
  46. Vasselli, J.R., M. Rosenbaum, A. Pietrobelli, R.L. Leibel, M. Nicholson, S.B. Heymsfield. Sexual Dimorphism in Circulating Leptin Concentrations is not accounted for by Dimorphism in Adipose Tissue Distribution. (Eighth International Congress on Obesity, Paris, France) Int. J. Obesity, 22 (Supplement 3):P87, 1998.
  47. Chagnon, Y.C., L. Perusse, W.K. Chung, R.L. Leibel, C. Bouchard. Linkage and Association between the Leptin Receptor (Lepr) Gene and Human Body Composition in the Quebec Family Study. (Eighth International Congress on Obesity, Paris, France) Int. J. Obesity, 22 (Supplement 3):O259, 1998.
  48. M. Boschmann, J. Hellmer, M. Nicolson, M. Blum, X.S. Wu-Peng, R. M. Macintosh, R.L. Leibel. Hyperleptinemia precedes hyperinsulinemia in neonatal fa k / fa k rats. (Eighth International Congress on Obesity, Paris, France) Int. J. Obesity, 22 (Supplement 3):O255, 1998.
  49. Leibel, R.L., W.K. Chung. Molecular Genetic Analysis of Human Obesity. (Eighth International Congress on Obesity, Paris, France) Int. J. Obesity, 22 (Supplement 3):O78, 1998.
  50. Simoneau, JA., M. Rosenbaum, M. Neverova, J. Hirsch, R.L. Leibel, C.H. Warden. Skeletal Muscle Uncoupling Protein-2 (UCP2) content is increased in subjects maintaining a 10% reduction in body weight. (Eighth International Congress on Obesity, Paris, France) Int. J. Obesity, 22 (Supplement 3):O222, 1998.
  51. Otabe, S., K. Clement, S. Dubois, R.L. Leibel, B.B. Lowell, W.K. Chung, P. Boutin, B. Guy-Grand, P. Froguel, F. Vasseur. Mutation Screeening of the human UCP3 gene in normoglycemic and NIDDM Obese patients. (Eighth International Congress on Obesity, Paris, France) Int. J. Obesity, 22 (Supplement 3):O21, 1998.
  52. Leibel, R.L. Genetic Obesities in Rodents, Genetic and Molecular Basis of Obesity, Satellite Symposium of 8th International Congress on Obesity. Paris, France, 1998.
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